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Joanna MaselWe identified protein domains in LUCA (<a href="https://ecoevo.social/tags/LastUniversalCommonAncestor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#LastUniversalCommonAncestor</a>). Their distinctive <a href="https://ecoevo.social/tags/AminoAcid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#AminoAcid</a> usage reveals the order amino acids were added to the <a href="https://ecoevo.social/tags/GeneticCode" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#GeneticCode</a>, based mostly on size. Older proteins hint at earlier alternative codes. 1/15 <a href="https://www.pnas.org/doi/10.1073/pnas.2410311121" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.pnas.org/doi/10.1073/pnas.2410311121</a> <a href="https://ecoevo.social/tags/astrobiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#astrobiology</a> <a href="https://ecoevo.social/tags/phylostratigraphy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#phylostratigraphy</a> <a href="https://ecoevo.social/tags/sulfur" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#sulfur</a> <a href="https://ecoevo.social/tags/metalloproteins" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#metalloproteins</a>

Giuseppe Michieli2 <a href="https://mstdn.science/tags/aminoacid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#aminoacid</a> residues in N-terminal region of <a href="https://mstdn.science/tags/polymerase" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#polymerase</a> acidic protein determine <a href="https://mstdn.science/tags/virulence" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#virulence</a> of Eurasian avian-like <a href="https://mstdn.science/tags/H1N1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#H1N1</a> swine <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#influenza</a> viruses in mice, J Virol.: <a href="https://journals.asm.org/doi/full/10.1128/jvi.01293-24?af=R" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://journals.asm.org/doi/full/10.1128/jvi.01293-24?af=R</a> We identified that 2 naturally occurring aa mutations in PA derived from <a href="https://mstdn.science/tags/H1N1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#H1N1</a>/2009 are crucial determinants of virulence of rEA H1N1 viruses & revealed differential mechanism by which these 2 mutations affect transcription & replication of vRNA.

Giuseppe Michieli<a href="https://mstdn.science/tags/Genetic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Genetic</a> & <a href="https://mstdn.science/tags/molecular" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#molecular</a> characterization of <a href="https://mstdn.science/tags/H9N2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#H9N2</a> avian <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#influenza</a> viruses in <a href="https://mstdn.science/tags/Yunnan" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Yunnan</a> Province, SW <a href="https://mstdn.science/tags/China" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#China</a>, Poul Sci.: <a href="https://www.sciencedirect.com/science/article/pii/S0032579124006199?via%3Dihub" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.sciencedirect.com/science/article/pii/S0032579124006199?via%3Dihub</a> Analysis of these <a href="https://mstdn.science/tags/aminoacid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#aminoacid</a> sites suggests that H9N2 influenza viruses in Yunnan continue to mutate and adapt to <a href="https://mstdn.science/tags/mammals" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#mammals</a> & are sensitive to <a href="https://mstdn.science/tags/neuraminidase" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#neuraminidase</a> <a href="https://mstdn.science/tags/inhibitors" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#inhibitors</a> but resistant to <a href="https://mstdn.science/tags/adamantanes" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#adamantanes</a>. It is necessary to strengthen surveillance of AIV H9N2 subtypes in poultry and LPMs in Yunnan to further understand their genetic diversity.

Giuseppe Michieli<a href="https://mstdn.science/tags/Aminoacid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Aminoacid</a> <a href="https://mstdn.science/tags/mutations" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#mutations</a> <a href="https://mstdn.science/tags/PB1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PB1</a>-V719M and <a href="https://mstdn.science/tags/PA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PA</a>-N444D combined with <a href="https://mstdn.science/tags/PB2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PB2</a>-627K contribute to the <a href="https://mstdn.science/tags/pathogenicity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#pathogenicity</a> of <a href="https://mstdn.science/tags/H7N9" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#H7N9</a> in <a href="https://mstdn.science/tags/mice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#mice</a>, Vet Res.: <a href="https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-024-01342-6" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-024-01342-6</a> Overall, this study revealed that <a href="https://mstdn.science/tags/virulence" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#virulence</a> in H7N9 is a <a href="https://mstdn.science/tags/polygenic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#polygenic</a> trait and identified novel virulence-related residues (PB2-627K combined with PB1-719M and/or PA-444D) in viral ribonucleoprotein (vRNP) complexes.

Giuseppe Michieli<a href="https://mstdn.science/tags/Avian" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Avian</a> <a href="https://mstdn.science/tags/H6" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#H6</a> <a href="https://mstdn.science/tags/Influenza" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Influenza</a> Viruses in <a href="https://mstdn.science/tags/Vietnamese" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Vietnamese</a> Live <a href="https://mstdn.science/tags/Bird" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Bird</a> <a href="https://mstdn.science/tags/Markets" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Markets</a> during 2018-2021 <a href="https://pubmed.ncbi.nlm.nih.gov/38543733/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1LGAx__djGAJ9poBzWGqPtjEbBDtz4ipSRRPUplmgHEyyF_Ihj&fc=None&ff=20240328065908&v=2.18.0.post9+e462414" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://pubmed.ncbi.nlm.nih.gov/38543733/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1LGAx__djGAJ9poBzWGqPtjEbBDtz4ipSRRPUplmgHEyyF_Ihj&fc=None&ff=20240328065908&v=2.18.0.post9+e462414</a> The Vietnamese H6 viruses analyzed here possess an <a href="https://mstdn.science/tags/aminoacid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#aminoacid</a> motif in <a href="https://mstdn.science/tags/HA" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HA</a> that confers <a href="https://mstdn.science/tags/binding" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#binding</a> to both avian- and human-type <a href="https://mstdn.science/tags/receptors" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#receptors</a> on host cells, consistent with their ability to infect <a href="https://mstdn.science/tags/mammals" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#mammals</a>.

Giuseppe MichieliA naturally occurring HA-stabilizing <a href="https://mstdn.science/tags/aminoacid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#aminoacid</a> (HA1-Y17) in an A(<a href="https://mstdn.science/tags/H9N2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#H9N2</a>) low-pathogenic <a href="https://mstdn.science/tags/influenza" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#influenza</a> virus contributes to <a href="https://mstdn.science/tags/airborne" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#airborne</a> <a href="https://mstdn.science/tags/transmission" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#transmission</a> <a href="https://pubmed.ncbi.nlm.nih.gov/38112470/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1LGAx__djGAJ9poBzWGqPtjEbBDtz4ipSRRPUplmgHEyyF_Ihj&fc=None&ff=20240117072001&v=2.18.0" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://pubmed.ncbi.nlm.nih.gov/38112470/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1LGAx__djGAJ9poBzWGqPtjEbBDtz4ipSRRPUplmgHEyyF_Ihj&fc=None&ff=20240117072001&v=2.18.0</a>

Jonathan WrightThe Birmingham child who paved the way for the heel prick test<a href="https://www.bbc.co.uk/news/uk-england-birmingham-67627128" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.bbc.co.uk/news/uk-england-birmingham-67627128</a><a href="https://mastodon.world/tags/Birmingham" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Birmingham</a> <a href="https://mastodon.world/tags/ChildrensHospital" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ChildrensHospital</a> <a href="https://mastodon.world/tags/Paediatrics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Paediatrics</a> <a href="https://mastodon.world/tags/PKU" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PKU</a> <a href="https://mastodon.world/tags/PhenylKetonUria" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PhenylKetonUria</a> <a href="https://mastodon.world/tags/Diet" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Diet</a> <a href="https://mastodon.world/tags/Protein" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Protein</a> <a href="https://mastodon.world/tags/AminoAcid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#AminoAcid</a>

Matt WillemsenAmino Acid Tryptophan Detected in Young Star Cluster Using infrared spectral data from NASA’s Spitzer Space Telescope, Instituto de Astrofísica de Canarias astronomer has detected the aromatic amino acid tryptophan in the interstellar gas of the young star cluster IC 348. This could be an indication that the molecule is widespread in interstellar space. <a href="https://www.sci.news/astronomy/interstellar-tryptophan-12020.html" rel="nofollow noopener noreferrer" target="_blank">https://www.sci.news/astronomy/interstellar-tryptophan-12020.html</a> <a href="https://fedibird.com/tags/tryptophan" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#tryptophan</a> <a href="https://fedibird.com/tags/StarCluster" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#StarCluster</a> <a href="https://fedibird.com/tags/spitzer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#spitzer</a> <a href="https://fedibird.com/tags/AminoAcid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#AminoAcid</a> <a href="https://fedibird.com/tags/infrared" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#infrared</a>

Joanna MaselOur preprint describes how <a href="https://ecoevo.social/tags/EffectivePopulationSize" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#EffectivePopulationSize</a> affects <a href="https://ecoevo.social/tags/AminoAcid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#AminoAcid</a> usage. <a href="https://www.biorxiv.org/content/10.1101/2023.02.01.526552v2" rel="nofollow noopener noreferrer" target="_blank">https://www.biorxiv.org/content/10.1101/2023.02.01.526552v2</a>. Within highly exchangeable pairs of amino acids, high Ne species are able to prefer <a href="https://ecoevo.social/tags/arginine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#arginine</a> over <a href="https://ecoevo.social/tags/lysine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#lysine</a>, and <a href="https://ecoevo.social/tags/valine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#valine</a> over <a href="https://ecoevo.social/tags/isoleucine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#isoleucine</a>. This matches <a href="https://ecoevo.social/tags/thermophile" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#thermophile</a> preferences, as expected from theories of marginal protein stability at mutation-selection-drift balance. 1/6 <a href="https://ecoevo.social/@hanonmcshea" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@hanonmcshea</a> <a href="https://ecoevo.social/tags/NearlyNeutralTheory" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NearlyNeutralTheory</a> <a href="https://ecoevo.social/tags/MolecularEvolution" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#MolecularEvolution</a> <a href="https://ecoevo.social/tags/EvolgenPaper" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#EvolgenPaper</a>

Steve Dustcircle 🌹Breaking Down <a href="https://masto.ai/tags/Proteins" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Proteins</a> to Build <a href="https://masto.ai/tags/FoodWaste" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#FoodWaste</a> Solutions <a href="https://www.the-scientist.com/the-marketplace/breaking-down-proteins-to-build-food-waste-solutions-71117" rel="nofollow noopener noreferrer" target="_blank">https://www.the-scientist.com/the-marketplace/breaking-down-proteins-to-build-food-waste-solutions-71117</a> <a href="https://masto.ai/tags/Aminoacid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Aminoacid</a> analysis helps <a href="https://masto.ai/tags/scientists" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#scientists</a> open the door to new <a href="https://masto.ai/tags/food" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#food</a> opportunities for healthier and more environmentally friendly <a href="https://masto.ai/tags/foodproduction" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#foodproduction</a>.

Jim Donegan 🎵 ✅<a href="https://mastodon.scot/tags/Kurzgesagt" class="mention hashtag" rel="tag">#Kurzgesagt</a> - 'You Are An Impossible <a href="https://mastodon.scot/tags/Machine" class="mention hashtag" rel="tag">#Machine</a>' <a href="https://www.youtube.com/watch?v=TYPFenJQciw&ab_channel=Kurzgesagt%E2%80%93InaNutshell" target="_blank" rel="nofollow noopener noreferrer" translate="no">https://www.youtube.com/watch?v=TYPFenJQciw&ab_channel=Kurzgesagt%E2%80%93InaNutshell</a> <a href="https://mastodon.scot/tags/Science" class="mention hashtag" rel="tag">#Science</a> <a href="https://mastodon.scot/tags/Biology" class="mention hashtag" rel="tag">#Biology</a> <a href="https://mastodon.scot/tags/Chemistry" class="mention hashtag" rel="tag">#Chemistry</a> <a href="https://mastodon.scot/tags/Probability" class="mention hashtag" rel="tag">#Probability</a> <a href="https://mastodon.scot/tags/MolecularBiology" class="mention hashtag" rel="tag">#MolecularBiology</a> <a href="https://mastodon.scot/tags/Cell" class="mention hashtag" rel="tag">#Cell</a> <a href="https://mastodon.scot/tags/Cells" class="mention hashtag" rel="tag">#Cells</a> <a href="https://mastodon.scot/tags/Protein" class="mention hashtag" rel="tag">#Protein</a> <a href="https://mastodon.scot/tags/Proteins" class="mention hashtag" rel="tag">#Proteins</a> <a href="https://mastodon.scot/tags/Life" class="mention hashtag" rel="tag">#Life</a> <a href="https://mastodon.scot/tags/LivingSystems" class="mention hashtag" rel="tag">#LivingSystems</a> <a href="https://mastodon.scot/tags/AminoAcid" class="mention hashtag" rel="tag">#AminoAcid</a> <a href="https://mastodon.scot/tags/AminoAcids" class="mention hashtag" rel="tag">#AminoAcids</a> <a href="https://mastodon.scot/tags/DNA" class="mention hashtag" rel="tag">#DNA</a> <a href="https://mastodon.scot/tags/ElectroMagnetism" class="mention hashtag" rel="tag">#ElectroMagnetism</a>

Dr David MartinThe <a href="https://genomic.social/tags/aminoAcid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#aminoAcid</a> <a href="https://genomic.social/tags/dice" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#dice</a> came out for today's <a href="https://genomic.social/tags/lecture" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#lecture</a>. Some innovative <a href="https://genomic.social/tags/edTech" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#edTech</a> that I probably need to refresh, but having <a href="https://genomic.social/tags/students" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#students</a> throwing a foam D20 around the <a href="https://genomic.social/tags/lectureTheatre" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#lectureTheatre</a> does help them <a href="https://genomic.social/tags/remember" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#remember</a> the lecture. And avoids it being a telephone directory reading dirge. <a href="https://genomic.social/tags/joke" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#joke</a> What is a <a href="https://genomic.social/tags/pirate" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#pirate</a>'s favourite amino acid?

Paul Sutton<a href="https://newsbots.eu/@ScienceDaily" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@ScienceDaily</a> Nice , and could have some useful medical applications I would guess. #'sciencedaily <a href="https://qoto.org/tags/chemistry" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#chemistry</a> <a href="https://qoto.org/tags/alcohol" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#alcohol</a> <a href="https://qoto.org/tags/aminoacid" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#aminoacid</a>

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